Human Quorum Sensing (HQS) - English
In bacteria, Quorum Sensing is a cellular communication mechanism based on the release and detection of signaling molecules (autoinducers). When the concentration of these molecules reaches a threshold ("quorum"), bacteria change their collective behavior (e.g., forming biofilms, emitting light, or releasing toxins). It's a form of group decision-making based on biochemistry.
The proposal suggests that humans also have an analogous system, where biochemical molecules signal group belonging and modulate social behaviors. Some examples:
Inflammatory cytokines: Molecules like IL-6 and TNF-α not only regulate immunity but are also linked to feelings of isolation or connection.
Example: People with chronic inflammation (as in depression) may have difficulty "tuning in" to social signals.
Butyrate (produced by the microbiome): It regulates not only gut health but also serotonin production, influencing mood and interactions.
Example: Gut dysbiosis (microbial imbalance) is associated with disorders like autism and anxiety.
Pheromones and body odors: Although controversial in humans, there is evidence that volatile compounds (like androstadienone) can synchronize emotions in groups (e.g., collective fear).
Autism and "detuning" of HQS:
The text mentions animal models with loss of delta-catenin (a protein linked to synapses). If cells cannot "hear" the group’s biochemical signals (such as cytokines or metabolites), social coordination fails.
This may explain why some individuals on the autism spectrum struggle to interpret unconscious social cues (which depend on these chemical signals).
Inequality and brain rigidity:
Chronic stress (such as that caused by social inequality) alters neuroplasticity. The brain under adversity becomes less adaptable—favoring rigid responses (e.g., hypervigilance) at the expense of social connection.
This echoes studies like "Impact of inequality on aging," which show how unequal environments accelerate neural aging.
Day and Night - Your Body in Action and at Rest
Día y Noche - Tu Cuerpo en Acción y en Reposo
Human Quorum Sensing (HQS) - English
Quorum Sensing humano (QSH) - Español
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Memórias Emocionais Pressão Visceral Respiração Contida e Produtividade - 478
O Dia Como Função - A Noite Como Significado
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